Body Dysmorphic Disorder
Conditions
Interventions
The study consist of two groups, one rTMS and one sham rTMS. Both will be
treated with a high frequency 10 Hz rTMS (HF-rTMS) protocol on the left
dorsolateral prefrontal cortex (dlPFC). rTMS treatme
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 65 years old; 2. Diagnosed with Body Dysmorphic Disorder (BDD), based on Body Dysmorphic Disorder - Yale Brown Obsessive Compulsive Scale (BDD-YBOCS); 3. Nonresponse (defined as
Exclusion criteria
Exclusion criteria: Exclusion criteria 1. Intracerebral metal implants (e.g. cochlear implant, brain stimulator); 2. (History of) epilepsy or epilepsy in a first degree relative; 3. Any other neurological disorder with seizure risk; 4. Acute suicidal ideations, or any psychological crisis (contact with the outpatient crisis service or admission in psychiatric hospital); 5. Bipolar disorder; 6. Current disorder in substance abuse (opiate, ketamine, LSD, (meth)amphetamine, cocaine, solvents, cannabis, benzodiazepines or barbiturate) or alcohol abuse; 7. Any known other serious somatic health problem; 8. Pregnancy; 9. Primarily autism spectrum disorder or primarily personality disorder (using SCID-5-P at baseline for personality disorders). Given that this is often seen secondarily in BDD patients. rTMS Contraindications: 1. History of epileptic seizures or epilepsy in a first degree relative, irregular sleep/ wake rhythm; 2. Cardiac demand pacemakers; 3. Implanted defibrillators; 4. Implanted neurostimulators; 5. Cochlear implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| More than 30% decrease (defined as response) in BDD-YBOCS questionnaires from baseline till end, and clinical improvement. | — |
Secondary
| Measure | Time frame |
|---|---|
| Furthermore a decrease in BABS, CGI, Sheehan, HDRS and HAS questionnaires are desirable. | — |
Countries
Netherlands
Outcome results
None listed