Neuropsychological deficits pediatric brain tumor
Conditions
Interventions
7T MRI, questionnaires, neuropsychological tests
Sponsors
Prinses Máxima Centrum voor Kinderoncologie
Eligibility
Age
2 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age between 6 and 23 years old - Have been treated for a posterior fossa brain tumor with surgery/chemotherapy only, focal proton radiotherapy, or cranial-spinal proton radiotherapy - At least 6 months and up to 5 years after diagnosis, and completed treatment - Able to complete MRI without anaesthesia
Exclusion criteria
Exclusion criteria: - No signed informed consent (either by patient and/or parents/legal guardian) - Insufficient knowledge of the Dutch language to perform the neuropsychological assessment or complete questionnaires - Significant visual, motor, or developmental problems and thus alternative neuropsychological assessments would be needed (e.g., blindness, deafness, profound developmental delay) - MRI-specific exclusion criteria, such as metal implants. Screening for MRI specific exclusion criteria will be done using the typical 7-Tesla MRI safety screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Age-standardized performance on a sustained attention task (K-CPT-2/CPT-3 measure) is the endpoint of the main analysis. The 7T MRI metrics measuring vasculature, metabolism, and white matter diffusion in the brain will be used to predict performance on this task. | — |
Secondary
| Measure | Time frame |
|---|---|
| Age-standardized performance on other neuropsychological measures (estimated IQ, working memory, processing speed, executive functioning, memory, visual-motor, questionnaires), clinical data (demographic, treatment, RT dose, complications), and premorbid history (birth, health, school, SES). | — |
Countries
Netherlands
Contacts
Public ContactM.H. Partanen
Prinses Máxima Centrum voor Kinderoncologie
Outcome results
None listed