glucose- en lipidenmetabolisme age-related muscle loss Sarcopenia
Conditions
Interventions
The intervention will be a fully controlled vegan diet with a duration of 10
days and will be compared to a fully controlled omnivorous diet with the same
duration. Participants will be randomized t
Sponsors
Wageningen Universiteit
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: Aged 65-79 years Community-dwelling Body Mass Index (BMI) 20-35 kg/m2
Exclusion criteria
Exclusion criteria: - Following a vegetarian or vegan diet during the six months prior to the study; - Following a diet that affects protein intake during the six months prior to the study; - >=5% of body weight loss during three months before the start of the study; - Participating in a structured exercise training program in the past 3 months; - Being diagnosed with one of the following: diabetes; renal disease; neurological or neuromuscular disorders;serious cardiovascular diseases; cancer; chronic obstructive lung disease (COPD); - Chronic use of medication that affects muscle function, e.g. corticosteroids, metformin, insulin; - The use of the following medicines: acenocoumarol (sintrom); phenprocoumon (marcoumar); dabigatran(pradaxa); apixaban (eliquis); rivaroxaban (xarelto); clopidogrel (plavix); combination of acetylsalicylic acid orcarbasalate calcium (ascal) with dipyridamole. - Allergic or intolerant to any product included in the diets; - Not willing to stop nutritional supplements, with the exception of supplements on medical advice, and vitamin D; - Not willing or afraid to give blood or undergo a muscle biopsy during the study; - Unwilling to eat a vegan and an omnivorous diet for ten days each; - Currently a research subject in another trial or participated in a clinical trial during 3 months before the start ofthe measurement period; - Not being able to understand Dutch; - Not having a general physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter includes the difference in muscle fractional synthesis rates (FSR; %/day) between the vegan diet and omnivorous diet. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include the difference in satiety, blood pressure, plasma blood glucose, insulin and lipid profile (HDL; LDL; cholesterol; triglycerides) between the vegan and the omnivorous diet. | — |
Countries
Netherlands
Outcome results
None listed