eye tumor uveal melanoma
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of primary UM 2. UM lesions arising from the choroid or ciliary body 3. No history of previous UM treatments 4. UM patients who will be treated with brachytherapy 5. Tumor prominence >3 mm
Exclusion criteria
Exclusion criteria: 1. Subjects who are not legally capable 2. Subjects under the age of 18 3. Contraindications to MRI scanning, including: o Claustrophobia o Pregnancy o Pacemakers and defibrillators o Nerve stimulators o Intracranial clips o Metallic fragments o Cochlear implants o Ferromagnetic implants o Hydrocephalus pump o Permanent make-up o Tattoos above the shoulders o Subjects who cannot keep their head still (eg. Tremor, Parkinson*s disease) o Severe physical restriction (eg. completely wheelchair dependent) o In the case of uncertainty about the MRI-contraindications, the MR-safety commission of the radiology department will decide whether this subject can be included in the study or not. 4. Contra indication for gadolinium such as renal insufficiency or contrast allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Tumor dimensions: Prominence, largest basal diameter, second basal diameter. 2. Changes in tumor dimensions, volume between the different time points. 3. Tumor apparent diffusion coefficient (ADC), time-intensity curve (TIC), pharmacokinetic parameters (Ktrans, Ve, Vp). | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional changes in the radiological appearance of the UM on MRI, such as: • Signal on T1 and T2 (measured relative to the choroid and eye muscle respectively) • Homogeneity of the lesion • Presence of retinal detachment • Localization compared to FAF | — |
Countries
Netherlands
Outcome results
None listed