non-melanoma skin cancer Skin cancer
Conditions
Interventions
Broad-spectrum UV-irradiation with repeated use of a home-installed UV-device
(the Sunshower medical) of the back skin at suberythemal dose, three times
every week during 10 minutes (0,8 SED per tim
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Individuals between 18 and 35 years. - Fitzpatrick skin types II, III, IV or VI - Individuals free of any dermatological or systemic disorder which would interfere with the results, at the discretion of the investigator. - Individuals who have read, understood, and signed an informed consent document relating to the specific study to which they are subscribing.
Exclusion criteria
Exclusion criteria: - Individuals taking medication which in the opinion of the investigator would mask or interfere with the results. - Individuals with chronic skin allergie - Individuals with suntan or sunburn. - Individuals with abnormal reactions to the sun. - Individuals who use oral supplementation of vitamin D - Subjects who used sun beds or were extensively exposed to UVR in the previous 30 days (e.g. during holidays), or are planning on doing so during the study - Subjects who consumed alcohol 1 day prior to MED assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimal erythemal dose-levels (MED) | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in thickness of stratum corneum (SC) and epidermal thickness, SC levels of immunological markers and urocanic acid isomers, levels of 25(OH)D3 in serum | — |
Countries
Netherlands
Outcome results
None listed