kidney stones Nephrolithiasis
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
16 Years to 64 Years
Inclusion criteria
Inclusion criteria: For this study, we identify four different groups of participants: Group 1: patients with primary hyperoxaluria. Group 2: patients with secondary or unspecified hyperoxaluria Group 3: patients with idiopathic calcium oxalate kidney stones disease. Group 4: control group of healthy volunteers. Inclusion criteria primary hyperoxaluria (group 1): - Age 16 - 60 years - Diagnosed with primary hyperoxaluria (type 1, 2 or 3), confirmed by genetic testing. Inclusion criteria secondary or unspecified hyperoxaluria (group 2): - Age 16 - 60 years - Diagnosed with secondary hyperoxaluria, confirmed by: hyperoxaluria (defined as > 0.5 mmol/1.73m2/day oxalate in 24-hours urine) and confirmed diagnosis of a disease as underlying secondary enteral cause of hyperoxaluria. - Diagnosed with unspecified hyperoxaluria. Inclusion criteria CaOx stone formers (group 3): - Age 16 - 60 years - Recurrent calcium oxalate stones Inclusion criteria healthy volunteers (group 4): - Age 16 - 60 years - Good health, no background of nephrolithiasis, kidney or gastrointestinal disease.
Exclusion criteria
Exclusion criteria: - eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To quantify dietary oxalate absorption from the gastrointestinal tract in patients with idiopathic CaOx kidney stones, primary hyperoxaluria, and secondary hyperoxaluria compared to healthy volunteers, by administering labelled oxalate. 2. To identify differences in the intestinal microbiome between these patient groups, by looking at the diversity and abundance of (oxalate degrading) bacteria. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To identify differences in the intestinal metabolome by measuring volatile and non-volatile organic compounds in the faeces and measuring labelled CO2 in exhaled air. | — |
Countries
Netherlands
Outcome results
None listed