brain
Conditions
Interventions
Transcranial Ultrasound Stimulation aimed at bilateral amygdalae and ventral
striatum (in separate sessions).
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Healthy participants between 18-40 years of age; - The ability and agreement to provide informed consent, and the ability to fulfil the study's requirements.
Exclusion criteria
Exclusion criteria: •Under 18 years of age •Current or planned pregnancy •Claustrophobia •A history or brain surgery or serious head trauma •A history of or any close relatives (parents, siblings, children) with epilepsy, convulsion, or seizure •Predisposition for fainting spells (syncope) •A cardiac pacemaker or intra-cardiac lines •An implanted neurostimulator •Implanted medication infusion device •Implanted metal devices or large ferromagnetic fragments in the head or upper body (excluding dental wire),or jewellery/piercing that cannot be removed •Use of a medical plaster that cannot or may not be taken off (e.g., nicotine plaster) •Cochlear implants •Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.) •Diagnosed neurological or psychiatric disorders •Use of psychoactive (prescription) medication (excluding anti-conception) •Skin disease at intended stimulation sites •The consumption of more than four alcoholic units within 24 hours before participation or any recreational drugs within 48 hours before participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Approach/avoidance choice behaviour as indicated by index-finger button-press will be used to assess the neuromodulatory effects of TUS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pupil size; Heart rate. These secondary study parameters fall under the blanket approval for standard research (CMO2014/288, version 3; titled: *Imaging Human Cognition*). | — |
Countries
Netherlands
Outcome results
None listed