Sickle Red blood Cell Survival: explaining heterogeneity

Sickle Red blood Cell Survival: explaining heterogeneity - SURVIVE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51617

Enrollment

Registered

2022-07-05

Start date

2023-03-28

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sickle Cell Anemia Sickle Cell Disease

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Sickle Cell Disease >=6 years old Clinical need for an erythrocyte transfusion

Exclusion criteria

Exclusion criteria: - No informed consent - Pregnancy, self-reported - Active cancer - Chronic of acute HIV infection - Comorbid autoimmune/inflammatory disease - Pre-operative incidental transfusion

Design outcomes

Primary

Measure	Time frame
- Survival of donor RBCs in top up and exchange transfusions in SCD patients 4 weeks post-transfusion - Effects of patient-derived factors (genotype, HbS%, hemolysis, endothelial activation (proVWF/VWF ratio), inflammation, neutrophil activity/phenotype) on donor RBC survival	—

Secondary

Measure	Time frame
- Phenotypic changes in endogenous and donor RBCs after transfusion in SCD patients (1 hour, 24 hours, 1 week, 2 weeks, 3 and 4 weeks post-transfusion) as compared to pre-transfusion - Oxidative stress in endogenous/donor RBCs after transfusion in SCD patients as expressed by intracellular metabolomics (1 hour, 24 hours, 1 week, 2 weeks, 3 weeks and 4 weeks post-transfusion) - Immediate and late effects of transfusion on neutrophil activity and phenotype in SCD patients (1 hour, 24 hours, 1 week and 2 weeks post-transfusion) as compared to pre-transfusion values - Survival of endogenous RBCs 1, 2 and 4 weeks after transfusion measured by the ratio of glycine-15N and glycine 14N in heme	—

Measure

Time frame

- Phenotypic changes in endogenous and donor RBCs after transfusion in SCD patients (1 hour, 24 hours, 1 week, 2 weeks, 3 and 4 weeks post-transfusion) as compared to pre-transfusion - Oxidative stress in endogenous/donor RBCs after transfusion in SCD patients as expressed by intracellular metabolomics (1 hour, 24 hours, 1 week, 2 weeks, 3 weeks and 4 weeks post-transfusion) - Immediate and late effects of transfusion on neutrophil activity and phenotype in SCD patients (1 hour, 24 hours, 1 week and 2 weeks post-transfusion) as compared to pre-transfusion values - Survival of endogenous RBCs 1, 2 and 4 weeks after transfusion measured by the ratio of glycine-15N and glycine 14N in heme

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Countries

Netherlands

Outcome results