Sex differences in the acute effects of guanfacine on activation of the brain stress system in individuals with an alcohol use disorder

Sex differences in the acute effects of guanfacine on activation of the brain stress system in individuals with an alcohol use disorder - SANE-study (Sex-differences, alcohol misuse and Negative Emotions)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51610

Enrollment

Registered

2022-01-21

Start date

2022-01-03

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psychische stoornissen, alcoholverslaving Alcohol use disorder

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Meeting at least 2 of the 11-DSM5 criteria for alcohol use disorder - age 25-45

Exclusion criteria

Exclusion criteria: - MRI contraindications - having a cardiovascular disease - the presence of cardiovascular risk factors (a history of sudden fainting without reason, a relative that died as a consequence of heart failure before the age of 60, a relative with pacemaker) - heartrate 30

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study is neural activation of the amygdala and changes in amygdala-PFC connectivity in response to negative emotional picture (compared to neutral pictures).	—

Secondary

Measure	Time frame
Secondary outcomes are i) neural activation of the amygdala and changes in amygdala-PFC connectivity in response to alcohol-related cues (compared to neutral cues), ii) alcohol and emotional cue-induced subjective responses (craving and arousal) iii) resting heart-rate variability and iv) glutamate concentrations in the dorsal anterior cingulate cortex (dACC) and v) resting state connectivity	—

Countries

Netherlands

Outcome results