Neuroscience research (basic science) brain
Conditions
Interventions
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Between 18-40 years of age - Right handed - The ability and agreement to provide informed consent, and the ability to fulfil the study's requirements
Exclusion criteria
Exclusion criteria: • Under 18 years of age • Current pregnancy • Claustrophobia • A history or brain surgery or serious head trauma • A history of or any close relatives (parents, siblings, children) with epilepsy, convulsion, or seizure • Predisposition for fainting spells (syncope) • A cardiac pacemaker or intra-cardiac lines • An implanted neurostimulator • Implanted medication infusion device • Implanted metal devices or large ferromagnetic fragments in the head or upper body (excluding dental wire), or jewellery/piercing that cannot be removed • Use of a medical plaster that cannot or may not be taken off (e.g., nicotine plaster) • Cochlear implants • Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.) • Diagnosed neurological or psychiatric disorders • Use of psychoactive (prescription) medication (excluding anti-conception) • Skin disease at intended stimulation sites • The consumption of more than four alcoholic units within 24 hours before participation or any recreational drugs within 48 hours before participation • All other criteria relevant to non-invasive brain stimulation as reported in the Donders Standard Operating Procedures for Non-Invasive Brain Stimulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will use electromyography (EMG) to measure motor-evoked potentials (MEPs) over the first dorsal interosseous (FDI) elicited by TMS applied over M1. Here, MEP peak-to-peak amplitude is our primary outcome measure. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine how well participants are able to discriminate between the ultrasound conditions (sham / active control / verum TUS), including when an auditory mask is played on top of active control and verum TUS, participants will be asked the following questions for 10 additional trials per condition: *Do you think you received ultrasonic stimulation (yes/no)?* and *On which side do you think you were stimulated (left/right)?*. Their accuracy/ability to discriminate between conditions is the secondary outcome of this study. | — |
Countries
Netherlands
Outcome results
None listed