Physiological MRI for precision radiotherapy of IDH-wildtype glioblastoma

Physiological MRI for precision radiotherapy of IDH-wildtype glioblastoma - PhysMRRT

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51604

Enrollment

Registered

2022-07-14

Start date

2022-08-01

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain tumor glioblastoma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Informed consent; • Adults (18 years or older); • diagnosed with IDH-wildtype GBM, as confirmed by pathology including molecular analysis post resection/biopsy; • referred to outpatient clinic of the Department of Radiotherapy to undergo standard treatment with high-dose RT. • Patients eligible for 30x2Gy or 15x2.67Gy

Exclusion criteria

Exclusion criteria: • Contraindication for MRI • Contraindication for use of gadolinium-based contrast agent (i.e. subject having renal deficiency) • Unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Equal prediction of pattern of failure (locations of tumour recurrence) based on the physiological CTV compared to the standard CTV used for radiotherapy planning, with the physiological CTV being smaller in volume.	—

Countries

Netherlands

Outcome results