Autoimmune disorder neuromuscular disease fluctuating muscle weakness
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
16 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Thymectomy at the MUMC+ - Capacity to give inform consent - Willingness to undergo clinical assessment (QMG, MG-ADL, QoL15) before thymectomy and at follow up visits - Willingness to donate blood pre-thymectomy and thymus tissue for research (required) - Willingness to donate bone barrow (optional) - Willingness to donate blood pre and post-thymectomy (required) (3-T Imaging additional inclusion criteria) - Willingness to undergo 3-T MRI pre-thymectomy - AChR-MG without suspicion of thymoma - Ability to perform breath holds
Exclusion criteria
Exclusion criteria: Exclusion criteria - Purely ocular AChR-MG - <16-years old 3-T Imaging exclusion criteria - Irregular heart rate - Inability to perform breath holds - Presence of ferro magnetic materials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Measure AChR autoantibodies in blood by RIA at different time points before, during and after treatment with immunomodulatory drugs. - Measure the total IgG titres in blood by ELISA. This can correlate to the aforementioned anti-AChR titres since predominantly AChR-MG is mediated via IgG. - Assess disease severity and treatment efficacy based on clinical response at different time points using MG-ADL - Identify the immune cell populations through FACs and microscopy analysis. - Identify TLH and increased germinal centres using 3-Tesla imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess disease severity and treatment efficacy based on clinical response at different time points using QMG and QoL15 | — |
Countries
Netherlands
Contacts
Public ContactP Martinez-Martinez
Universiteit Maastricht
Outcome results
None listed