polycystic ovary syndrome
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age 18-45years (premenopausal) - Caucasian - Willing to provide vaginal swab and stool sample - Willing to provide informed consent - Sufficient command of the Dutch language - Diagnosed with PCOS at Erasmus MC using the Rotterdam criteria by a presence of at least two of the following criteria o Clinical or biochemical hyperandrogenism (modified Ferriman-Gallway score >5; testosterone level >2nmol/L, Free Androgen Index > 2.9) o Oligomenorrorrhea or amenorrhea o Polycystic ovaries. Control group: o Age 18-45years o Caucasian o Willing to provide vaginal and stool sample o Willing to provide informed consent o Regular menstrual cycle (25-35days) o Sufficient command of the Dutch language o No history of diagnosed PCOS and do not meet any of the Rotterdam criteria.
Exclusion criteria
Exclusion criteria: - BMI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in community structure of the gut microbiome between PCOS patients and controls as such and its diagnostic and metabolic characteristics. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Differences in community structure in the vaginal microbiome between PCOS patients and controls as such and its diagnostic and metabolic characteristics. - Differences and similarities in community structure of the vaginal- and gut microbiome in PCOS patients - Differences and similarities between the vaginal- and gut microbiome composition between overweight/obese and lean patients (with/without PCOS) - To analyse potential metabolic profiles characterizing different phenotypes of PCOS | — |
Countries
Netherlands
Outcome results
None listed