Contrasting the Neural Systems of Social and Non-social Threat Regulation in the Adolescent Brain

Contrasting the Neural Systems of Social and Non-social Threat Regulation in the Adolescent Brain - FearLess

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51563

Enrollment

200

Registered

2022-11-04

Start date

2023-08-23

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extinction learning

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: - Fluent Dutch speaker - 9-16 years old - Right-handed

Exclusion criteria

Exclusion criteria: - Participants with current use of psychotropic medications (unless they quit 24 hours before participation) or oral contraceptives - (Possible) pregnancy in females - Current and/or past psychiatric conditions - Current and/or past neuroendocrine conditions - Current and/or past epilepsy or head trauma - Contraindications for MRI, including: metal implants (including braces), heart arrhythmia and claustrophobia.

Design outcomes

Primary

Measure	Time frame
In each session participants will undergo a structural MRI scan and an fMRI scan whilst performing tasks. The main study parameter is the Blood Oxygen Level Dependent response (BOLD-response) in the threat regulation brain network during implicit and explicit forms of social versus non-social threat regulation.	—

Secondary

Measure	Time frame
The secondary parameters include: - The resting-state fMRI - Sex-steroid hormones - Fear conditioning response - Reactivity and regulation response Other parameters (questionnaires for participants) * Exit questionnaire - perception of observed learning model * Pubertal development * Subtests of an IQ test * Peer influence * General symptoms of psychopathology / anxiety / depression * Early-life stress * Resilience * Sleep Other parameters (questionnaires for parents) * Early & current adolescent life events * Socio-Economic Status (SES) * Sleep	—

Measure

Time frame

The secondary parameters include: - The resting-state fMRI - Sex-steroid hormones - Fear conditioning response - Reactivity and regulation response Other parameters (questionnaires for participants) * Exit questionnaire - perception of observed learning model * Pubertal development * Subtests of an IQ test * Peer influence * General symptoms of psychopathology / anxiety / depression * Early-life stress * Resilience * Sleep Other parameters (questionnaires for parents) * Early & current adolescent life events * Socio-Economic Status (SES) * Sleep

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Countries

Netherlands

Outcome results