Fysiologie van voedselverwerking. N.v.t.
Conditions
Interventions
None listed
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age between 18 and 30 years - BMI between 18.5 and 25 kg/m2 - Apparently healthy (self-reported) - Right-handed - Sufficient blood hemoglobin (Hb) levels (women > 7,5; men > 8.5 g/dl) and having antecubital veins suitable for blood sampling via a catheter - Willing to be informed about incidental findings of pathology and consenting to informing their general practitioner about this.
Exclusion criteria
Exclusion criteria: - Having disturbances of glucose metabolism such as being prediabetic or diabetic - Use of medication that could influence study results including insulin/metformin/proton pump inhibitors, antacids, anti-depressants - Allergy or intolerance for any of the study products/compounds (sucrose, sucralose, stevia extraxt, allulose, monk fruit extract) - Being a regular smoker (smoking more than one cigarette or e-cigarette with nicotin per day) - Drinking more than 14 glasses of alcohol a week - Having genetic, psychiatric or neurological diseases affecting the brain - Gastric disorders or regular gastric complaints (more than once per week), for example heart burn - Having renal or hepatic disease - Using recreational drugs more than once per week (e.g. marihuana, XTC, GHB, laughing gas) - Having given a blood donation in the past two months - Being pregnant, lactating or planning on becoming pregnant during the study - Currently following or having followed calorie-restricted diet in the past two months - Participating in other research during the study period - Not having a general practitioner - Being an employee or student of the Division of Human Nutrition and Health - Having a contra-indication to MRI scanning, including, but not limited to: o Pacemakers and defibrillators o Intraorbital or intraocular metallic fragments o Other metal objects on/in the head which cannot be removed o Ferromagnetic implants o Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rCBF in a priori defined homeostatic and reward-related brain regions of interest (ROIs; hypothalamus, striatum). | — |
Secondary
| Measure | Time frame |
|---|---|
| Seed-based functional connectivity of the ROIs. Plasma glucose and insulin. Gastric content volume. | — |
Countries
Netherlands
Outcome results
None listed