high blood pressure
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age >=70 years. - Clinical Frailty Scale >=4 and =150 mmHg without antihypertensive treatment, or; • Uncontrolled systolic hypertension, i.e. office systolic blood pressure >=150 mmHg despite antihypertensive treatment. - Will be starting (untreated) or adding (uncontrolled) antihypertensive treatment in the near future for (further) reducing systolic blood pressure by >=10 mmHg while reaching a treatment target of office systolic blood pressure
Exclusion criteria
Exclusion criteria: - Unable to provide signed and dated informed consent form. - Mentally incompetent subjects (e.g. due to dementia) as assessed by a physician. - Currently enrolled in another interventional study targeting either blood pressure and/or cerebral blood flow. - Cardiovascular event within the past 3 months. - Severe renal disease (eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in resting CBF from baseline to follow-up (i.e. the average of the in duplo follow-up assessments). | — |
Secondary
| Measure | Time frame |
|---|---|
| - The change in orthostatic tolerance and measures of cerebral autoregulation, i.e. dynamic cerebral autoregulation and baroreflex sensitivity, from baseline to follow-up (i.e. the average of the in duplo follow-up assessments). - The number/percentage of patients that demonstrate a >10% decrease in CBF from baseline to follow-up. - In addition to (reductions in) mean CBF, the number and duration of episodes (during continuous monitoring of CBF) where CBF is reduced by >10% from the mean baseline value. | — |
Countries
Netherlands
Outcome results
None listed