Circadian synchronisation energy metabolism Circadian synchronisation energy metabolism
Conditions
Interventions
patients will receive nocturnal parenteral nutrition for 1 week (period A) and
will switch to diurnal parenteral nutrition (period B) for 1 week. At the start
of the study, patients will be randomly
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Chronic intestinal failure Parenteral nutrition for at least 3 nights a week Parenteral nutrition for more than 1 year No major changes in parenteral nutrition for 3 months prior to inclusion
Exclusion criteria
Exclusion criteria: Parenteral infusion for more than 16 h a day Use of bone modifying drugs in the last 2 years Bone fractures in the past year Renal insufficiency (eGFR =53 mmol/ml Use of corticosteroids (systemic, cutaneous >5cm2 or WHO class I-III) Shift work Performing intensive exercise (> 2 hours a day and > 3 times a week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in the bone turnover markers serum P1NP and CTX-1, changes in glucose variability measured by a continuous glucose monitor and changes in insulin levels. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in nitrogen balance, sleep/wake rhythm, clock gene expression, resting energy expenditure and substrate oxidation rates, body temperature | — |
Countries
Netherlands
Contacts
Public ContactG.M. Werf
Amsterdam UMC
Outcome results
None listed