Value of MRCP+ And Liver Multiscan in the management of Dominant strictures in primary sclerosing cholangitis

Value of MRCP+ And Liver Multiscan in the management of Dominant strictures in primary sclerosing cholangitis - MALD study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51520

Enrollment

Registered

2022-05-05

Start date

2022-08-26

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dominant strictures in PSC patients

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Established diagnosis according to the IPSCSG Definitions Clinically suspected of a dominant stricture Age >= 18 Able to give informed consent

Exclusion criteria

Exclusion criteria: Insufficient image quality Known allergy for MRI contrast agents Implants that are non-compatible with MRI scanner

Design outcomes

Primary

Measure	Time frame
Change in total biliary volume by MRCP+ and cT1 value by LMS at 8 weeks after endoscopic treatment of dominant strictures.	—

Secondary

Measure	Time frame
Change in total biliary volume by MRCP+ and cT1 value by LMS at 8 weeks after a second endoscopic treatment of dominant strictures Consistency of MRCP+ metrics and cT1 value by LMS when endoscopic treatment is not performed. Correlation of MRCP+/Liver Multiscan with modified Amsterdam classic cholangiography scoring. Correlation of imaging features of MRCP+ with classic cholangiography in individual areas of interest by two independent assessors. Correlation of dominant strictures rated by MRCP+/Liver Multiscan with those assessed by classic definition of DS. Reproducibility of DS not treated by ERC at baseline and at 8 weeks as determined by two independent assessors.	—

Measure

Time frame

Change in total biliary volume by MRCP+ and cT1 value by LMS at 8 weeks after a second endoscopic treatment of dominant strictures Consistency of MRCP+ metrics and cT1 value by LMS when endoscopic treatment is not performed. Correlation of MRCP+/Liver Multiscan with modified Amsterdam classic cholangiography scoring. Correlation of imaging features of MRCP+ with classic cholangiography in individual areas of interest by two independent assessors. Correlation of dominant strictures rated by MRCP+/Liver Multiscan with those assessed by classic definition of DS. Reproducibility of DS not treated by ERC at baseline and at 8 weeks as determined by two independent assessors.

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Countries

Netherlands

Outcome results