Major depressive disorder
Conditions
Interventions
High frequency rTMS (10Hz, 4 seconds stimulation, inter train interval of 11
seconds, 75 trains) on the left dorso lateral Prefrontal Cortex (dlPFC), for 20
sessions.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age 18 to 65 years old; Diagnosed with Major Depressive Disorder, current episode depressive Indication for rTMS, as indicated by a psychiatrist Therapy resistance defined by non-response after at least one type of antidepressant and one adequate psychotherapy
Exclusion criteria
Exclusion criteria: Diagnosis of bipolar disorder Current depressive episode with psychotic traits Acute suicidality (History of) neurological disease; (History of) epilepsy; Pregnancy Abnormal hearing or (uncorrected) vision; Current disorder in substance abuse (opiate, ketamine, LSD, (meth)amphetamine, cocaine, solvents, cannabis, benzodiazepines or barbiturate) or alcohol abuse; Any known other serious somatic health problem; Used alcohol within the last 24 hours prior to each test session; Used recreational drugs over a period of 72 hours prior to each test session. rTMS contraindications: ICD, pacemaker, epilepsy in a first degree relative and intracranial metal implants, such as a cochlear implant or deep brain stimulator.. MRI contraindications: metal implants, claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression outcome is measured using a Hamilton Depression Rating Scale - 17 items and the Inventory of Depressive Symptoms - self rated every 5 sessions. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in heart frequency using electrocardiogram (ECG) before and during stimulation 2. Changes in E/I ratio using electroencephalogram (EEG) before, during and (directly) after stimulation. 3. Changes in functional brain connectivity using functional MRI. | — |
Countries
Netherlands
Outcome results
None listed