metabolic diseases metabolic myopathy
Conditions
Interventions
During a unilateral intervention period of 14 days, participants will perform
high intensity dynamic knee extension training with one leg every other day (in
total seven sessions). Based on leg domi
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age >= 18 years - m.3243A>G point mutation or single, large scale mtDNA deletion
Exclusion criteria
Exclusion criteria: * insufficient mastery of the Dutch language * pregnancy * severe cardiopulmonary disease (chest pain, heart failure, arrhythmia, pacemaker, cardiac surgery, severe exertional dyspnea, emphysema). If cardiac involvement is present, inclusion will be evaluated by one of the cardiologists with expertise in mitochondrial cardiomyopathy. * coagulopathy (anti-platelet therapy is allowed) * cognitive dysfunction * not able to perform the high intensity training protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters include mitochondrial and myofibrillar protein synthesis rates of vastus lateralis muscle, calculated from the increase in enriched deuterized alanine in muscle tissue. The trained muscle will be compared with the untrained muscle after 14 days of aerobic exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are muscle tissue amino acid composition and nitrogen content. Also mitochondrial respiration of muscle tissue from the trained and untrained leg will be compared to baseline tissue using the Oroboros technique. | — |
Countries
Netherlands
Outcome results
None listed