pulmonary hypertension right heart failure
Conditions
Interventions
The usual dosage diuretics as prescribed by the medical specialist will be
temporarily withdrawn for one week.
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosed with idiopathic PAH, hereditary PAH, drug- and toxins induced PAH or CTEPH, according to ESC/ERS pulmonary hypertension guidelines - Minimal dosage of 40mg furosemide or 1mg bumetanide a day - NYHA classification II - Age >=18 and
Exclusion criteria
Exclusion criteria: - Pregnant subjects - Inability to provide informed consent - Change in PAH specific therapy within 3 months before diuretic withdrawal - Change in (dose of) any other medication - Hospitalized for acute decompensation within one year before diuretic withdrawal - One or more of the following co-morbidities:, uncontrolled systemic hypertension (>140/90 mmHg) , renal failure (eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volumes: Right atrial end reservoir volume, right atrial volume at end active emptying, right atrial volume at end passive emptying, right ventricular end diastolic volume (RVEDV) (ml), right ventricular end systolic volume (RVESV) (ml) Function: Right atrial reservoir volume, right atrial passive emptying volume, right atrial active emptying volume, right ventricular ejection fraction (RVEF) (%) Contractility: right atrial and right ventricular strain, NT-pro BNP levels | — |
Secondary
| Measure | Time frame |
|---|---|
| Other study parameters: bodyweight, 6-minute walking distance, potassium, sodium, creatinine, stroke volume, flow | — |
Countries
Netherlands
Outcome results
None listed