diabetes Impaired glucose tolerance
Conditions
Interventions
Participants will consume test products that fall in the same food category,
but differ in glycaemic index/carbohydrate content. Part of these products is
provided by industrial partners, of which t
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Apparently healthy men and women; • BMI of 25 - 40 kg/m2; • Age 45-75 years; • Weight stable (±
Exclusion criteria
Exclusion criteria: • Diagnosed with type 1 or type 2 diabetes; • Diseases or prior surgeries affecting the stomach, liver, or intestines; • Food allergies/intolerances for products used in the study design; • Receiving medication or supplements interfering with glucose metabolism (as judged by our research physician); • Regular use of medication interfering with immune function (e.g. corticosteroids, immune blockers, as judged by our research physician); • Donated blood within 2 months prior to the screening; • Anaemia defined as Hb concentrations =14 alcoholic beverages per week for women and >=21 alcoholic beverages per week for men; • Being pregnant or lactating; • Use of soft and/or hard drugs; • Unable/unwilling to download a research application on the mobile phone; • Participation in another study that involves an intervention within two months prior to the intervention; • Working at the division of Human Nutrition and Health of Wageningen University and Research or the Food, Health and Consumer research group of Wageningen University and Biobased Research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is glucose concentration as measured by continuous glucose monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Short-term well-being, as assessed by questionnaires, and meal timing will be related to glucose responses. In addition, glucose responses will be related to phenotype, as measured by an array of different outcome parameters: • Anthropometrics: weight, height, waist and hip circumference, body composition (MRI/MRS), body fat distribution (MRI/MRS) • Fasting plasma glucose parameters: HbA1c, glucose concentration, insulin concentration • Immune function: PBMC RNA expression, Monocyte RNA expression, Monocyte response upon TLR activation • Oxidative stress: Plasma and urinary biomarkers • Advanced glycation end-products: AGE accumulation (AGE reader), plasma concentrations of a-dicarbonyls and AGEs • Cognitive performance (CANTAB) • Microbiota and gut health: Microbiota composition (faeces and saliva), transit time, stool frequency (Bristol stool chart), stool consistency (Bristol stool chart) • Amylase: concentration and activity (saliva samples) • Genetic variation: SNPs in amylase genes and in genes relevant for metabolism and metabolic responses to food (mouth swap) • Circulating metabolites: Fasting and following a high-fat mixed meal challenge | — |
Countries
Netherlands
Outcome results
None listed