Does High Flow Nasal Cannula (HFNC) facilitate CO2-washout during EBUS under procedural sedation?

Does High Flow Nasal Cannula (HFNC) facilitate CO2-washout during EBUS under procedural sedation? - Does HFNC facilitate CO2-washout during EBUS?

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON51455

Enrollment

Registered

2022-06-28

Start date

2022-10-10

Completion date

Unknown

Last updated

2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedatie High flow nasal cannula ventilation

Interventions

The patients will start with 3L O2/min through a nasal cannula. This will be replaced by HFNC after 10 minutes, which will be set with a flow of 30 or 70 L/min, depending on the randomisation. After

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult patients scheduled for EBUS with sedation COPD gold class 3-4

Exclusion criteria

Exclusion criteria: - Neuromusculaire diseases, such as Guillan Barre, MS, ALS - allergy to propofol or esketamine - Systolic pulmonary pressure > 60 mmHg - Pregnancy - Children (age

Design outcomes

Primary

Measure	Time frame
The CO2-washout will be measured by: - insp CO2 - exp CO2 - CO2-waveform analysis	—

Secondary

Measure	Time frame
Secundary outcomes will be: - a difference in CO2-washout in different levels of the trachea (carina en left main bronchus). - a flow-dependency There will be controlled for capillary CO2.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Jul 23, 2026