onderzoek bij gezonde vrijwilligers not applicable
Conditions
Interventions
Participants will receive standard 600 pulses of continuous theta-burst
stimulation (bursts of three pulses at 50 Hz every 200 ms) at 45% of machine
intensity for 40 seconds, to either the medial ce
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Healthy; Between 18 and 35 years of age; Righthanded; Nonsmoking; Normal or corrected-to-normal vision; Willingness and ability to understand the nature and content, to participate and to comply with the study requirements; Willingness and ability to give written informed consent.
Exclusion criteria
Exclusion criteria: (1) Use of medication and drugs (except oral contraceptives); (2) Pregnancy or possible pregnancy; (3) Head trauma or underwent brain surgery; (4) Neurological or psychiatric condition; (5) Epilepsy or family history of epilepsy; (6) Metal in the head (except for bridges behind the teeth); (7) Heart problems; (8) Pacemaker or neurostimulator; (9) Medication pump; (10) Electronic hearing device; (11) Consumption of more than 3 alcoholic beverages a day; (12) Participation in a non-invasive brain stimulation study in the past 28 days; (13) Previous participation in 10 or more non-invasive brain stimulation studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is reversal learning performance (e.g., how fast participants notice and implement a change in reward-punishment contingencies) as a function of cTBS condition during a computer task. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are risk-taking as a function of cTBS condition during a computer task, and the moderating effects of state anger, state anxiety, trait aggression, trait impulsivity and vagally mediated HRV on risk-taking and reversal learning performance by cTBS condition. | — |
Countries
Netherlands
Outcome results
None listed