blood glucose pre-diabetes
Conditions
Interventions
12-week intervention with 3.6 g/d dried bitter-gourd supplements or a reference
intervention with 3.6 g/d dried cucumber supplements.
Sponsors
Wageningen Food and Biobased Research
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age 40-75yrs • BMI >25 kg/m2 • Having a fasting glucose >= 5.6 mmol/L
Exclusion criteria
Exclusion criteria: • Use of medication/supplements that may influence the study results, such as metformin, gliclazide, glimepiride, tolbutamide, insulin, sitagliptin (DPP4 inhibitor), liraglutide (GLP-1 agonist), acarbose, repaglinide, pioglitazone, corticosteroids (systemically) , SGLT-2 inhibitors, (judged by our research physician) • Having a fasting glucose >11.0 mmol/L • History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints • History of liver dysfunction (cirrhosis, hepatitis) or liver surgery • Kidney dysfunction (self-reported) • Reported slimming, medically prescribed or other extreme diets • Reported weight loss or weight gain of > 5 kg in the month prior to pre-study screening • Not willing to give up blood donation during the study • Current smokers • Alcohol intake >=14 glasses (women) or >21 glasses (men) of alcoholic beverages per week, on average • Not pregnant or lactating • Abuse of illicit drugs (soft- and hard drugs) • Food allergies for products that we use in the study • Participation in another clinical trial at the same time • Being an employee of the Food, Health & Consumer Research group of Wageningen Food & Biobased Research or dept. human nutrition and health of Wageningen University.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is fasting levels of plasma glucose. | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed