The Neurobiological basis of persisting fatigue and cognitive complaints as a consequence from COVID-19

The Neurobiological basis of persisting fatigue and cognitive complaints as a consequence from COVID-19 - VeCosCO

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51404

Enrollment

200

Registered

2022-04-22

Start date

2022-05-02

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

long COVID-19 (>3 maanden na acute infectie) long COVID-19: chronic fatigue syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - At least 3 months after diagnosis of COVID-19 (hospitalized or non-hospitalized) confirmed by a positive PCR for SARS-CoV-2, positive SARS-CoV-2 serology or CO-RADS (COVID-19 Reporting and Data System) >=4 on CT-scan, or antigen quicktest. For post COVID-19 participants with long-term fatigue and cognitive complaints - Experience severe fatigue after going through COVID-19 (>40 on the fatigue scale of the Checklist Individual Strength (CIS)(Worm-Smeitink et al., 2017)) - A score of >=18 on the concentration subscale of the CIS, at least 3 months after COVID-19 For post-COVID-19 participants without persisting fatigue and/or cognitive complaints - No severe fatigue on the Checklist Individual Strength (CIS)(Worm-Smeitink et al., 2017)) (score

Exclusion criteria

Exclusion criteria: Subject who meets any of the following criteria will be excluded from participation in this study: - Known psychiatric or somatic conditions prior to COVID-19 that could explain the fatigue or cognitive symptoms. - Disabling fatigue and/or cognitive complaints prior to COVID-19. - Re-infection with SARS-CoV-2 within the last 3 months

Design outcomes

Primary

Measure	Time frame
Persistent fatigue and cognitive complaints	—

Secondary

Measure	Time frame
2. Impact of persistent complaints on health-related quality of life, health care consumption 3. Risk factors for persistent fatigue and cognitive problems: cognitive behavioural factors (coping, illness perceptions) , cognitive neuropsychological functioning sociodemographic factors (eg. age, gender), medical factors (severity of initial covid19 infection, ICU admission, vaccination status, comorbidity, covid19 virus variant) 4. Post-exertional malaise	—

Measure

Time frame

2. Impact of persistent complaints on health-related quality of life, health care consumption 3. Risk factors for persistent fatigue and cognitive problems: cognitive behavioural factors (coping, illness perceptions) , cognitive neuropsychological functioning sociodemographic factors (eg. age, gender), medical factors (severity of initial covid19 infection, ICU admission, vaccination status, comorbidity, covid19 virus variant) 4. Post-exertional malaise

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Countries

Netherlands

Outcome results