Inflammation markers, blood oxidative stress and working memory capacity in patients with GHB use disorder undergoing detoxification

Inflammation markers, blood oxidative stress and working memory capacity in patients with GHB use disorder undergoing detoxification - Blood biomarkers and working memory in GUD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51379

Enrollment

Registered

2022-07-08

Start date

2022-10-03

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

GHB addiction GHB use disorder

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: • Diagnosed with a GHB use disorder according to the DSM V • Undergoing GHB detoxification through pharmaceutical GHB titration and tapering • 18 years or older

Exclusion criteria

Exclusion criteria: • Patient who have acute psychiatric co-morbidity that require immediate medical attention and interferes with the execution of the study, such as mania, delirium and psychosis • Insufficient understanding of the Dutch language • Patients with a phobia of needles • Patient is pregnant (this will be checked upon admission as a part of the regular treatment protocol)

Design outcomes

Primary

Measure	Time frame
Cytokines IL-6, IL-8, IL-10, TNF-a, and oxidative stress markers malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD) and 8-OHdG	—

Secondary

Measure	Time frame
Results on the cognitive tasks digit span task and corsi block tapping tasks.	—

Countries

Netherlands

Outcome results