The role of inflammation in the pathogenesis of tinnitus

The role of inflammation in the pathogenesis of tinnitus - Inflammation in tinnitus

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51359

Enrollment

100

Registered

2022-05-18

Start date

2022-05-19

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ringing in the ears Tinnitus

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Adult, aged 18 years or older; - Hearing threshold: average of 1000kHz, 2000kHz & 4000kHz

Exclusion criteria

Exclusion criteria: - Objective tinnitus. - Presence of neurological disease (apart from tinnitus) - Presence of inflammatory disease, or the use of anti-inflammatory medication. - Presence or history of a malignancy - Presence of a disease of the ear (e.g. chronic otitis media, otosclerosis, previous surgery etc). - Presence of an coagulation disorder - Presence of a serious psychiatric disorder. - Pregnancy

Design outcomes

Primary

Measure	Time frame
The main study parameters are blood cytokine levels of TNF-a, IL-1β, IL-6, IL-10 and IFN-γ.	—

Secondary

Measure	Time frame
Complete blood count measures (neutrophil count, lymphocyte count, thrombocyte count, Mean Platelet Volume (MPV), Mean Corpuscular Volume (MCV), Platelet Distribution Weight (PDW), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)).	—

Countries

Netherlands

Outcome results