glucosemetabolismestoornissen postprandial lipid and glucose metabolism
Conditions
Interventions
None listed
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Male or female - Age 45-75 y - BMI 25-35 kg/m2 - Suitable veins for insertion of cannula
Exclusion criteria
Exclusion criteria: - Having a gastro-intestinal disease, such as celiac disease, Crohn*s disease, or Ulcerative colitis - Having a history of intestinal surgery that might interfere with study outcomes, as determined by the medical supervisor. This does not include an appendectomy or cholecystectomy - Presence of significant systemic diseases, such as diabetes mellitus, cancer, cardiovascular disease or respiratory disease, as determined by the medical supervisor - Use of medications known to interfere with glucose or lipid homeostasis (e.g. corticosteroids, cholesterol-lowering medication, insulin, metformin), as determined by medical supervisor - Blood clotting disorders - Unstable body weight (weight gain or loss >3 kg in the past three months) - Reported slimming, medically prescribed or other extreme diets - Alcohol consumption >21 glasses a week - Anaemia (Hb values
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the postprandial triglyceride responses in blood upon a mixed meal challenge. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are: postprandial glucose and insulin responses in the blood upon a mixed meal challenge, and extensive phenotyping of the subjects by collecting data on fasting blood profiles of micronutrients, metabolites, and proteins, continuous blood glucose levels (Freestyle Libre), body fat composition (DEXA), liver fat percentage (MRI), habitual dietary intake (FFQ), and physical activity (ActivPAL3). | — |
Countries
Netherlands
Outcome results
None listed