Diabetes in Pregnancy Gestational Diabetes
Conditions
Interventions
None listed
Sponsors
Zuyderland Medisch Centrum
Eligibility
Inclusion criteria
Inclusion criteria: having a confirmed single, viable pregnancy past 20 weeks gestation Diagnosed GDM and treated with Metformin (as prescribed by Ob/Gyn)
Exclusion criteria
Exclusion criteria: pre-existing diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study parameters will be collected at mid-gestation (24-27 weeks), end gestation (35-37 weeks), and 6 weeks after delivery, as indicated in Table 1. Primary outcomes of this study will be time in range during 7 days continuous glucose monitoring. Requirement for additional insulin-treatment will be abstracted from medical records and reported in %. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin sensitivity and sensitivity will be calculated as Matsuda-Index and Stumvoll-indices, using the available samples of the routine OGTT, namely 0, 60 and 120 min: Matsuda = 10,000/ SQRT(Gluc0 * INS0 * Glucmean * INSmean); Stumvoll(1st) = 1194 + 4.724 × Ins0 * 117.0 × Gluc60 + 1.414 × Ins60. Women will be classified as having low insulin secretion and/or low insulin sensitivity as | — |
Countries
Netherlands
Outcome results
None listed