corpulence fatness Overweight
Conditions
Interventions
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Bariatric surgery 24-36 months prior to the study - Adult (over 18y old) - Mentally capable to understand the consequences of the procedure and make his or her own choice without coercion - Able to undergo PET and MRI, according to the investigator*s assessment - Able to participate in follow-up - Written informed consent
Exclusion criteria
Exclusion criteria: - Presence of a DSM-IV axis 1 disorder - The use of drugs that bind to dopamine D2/3 receptors, including various classes of antipsychotics and antidepressants - History of stroke, brain tumor, Parkinson*s Disease or dementia - Alcohol or substance abuse in the last 6 months - Alcohol consumption 24h prior to PET scanning - Smoking or other forms of nicotine intake 12 hours prior to PET scanning - Use of anorectic drugs in the last 6 months - Current pregnancy - Medication for Diabetes Mellitus - Claustrophobia - The presence of implanted metal objects of the type which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field (such as certain implanted devices, shrapnel, ocular metal shavings) - Patients with a bodyweight > 200kg will be excluded to ensure the maximum load of the camera bed of the PET-scanner (227 kg) is not exceeded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pre- and post-eating differences in dopamine D2 receptor availability as indexed by the [11C]-raclopride binding potential in the brain*s reward system between subjects who underwent successful vs unsuccessful bariatric surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation between questionnaires on eating habits (EDE-Q, REO, YFAS) and quality of life (OBESI-Q) in patients who had successful vs unsuccessful BS and [11C]-raclopride binding potential. The relation between fasting or fed (gut) hormone concentrations and dopamine D2 receptor availability in the reward system . | — |
Countries
Netherlands
Outcome results
None listed