CIN leasions premalignancy of cervical cancer
Conditions
Interventions
Cervical cytology, vaginal swab and/or biopsy
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age>=18 years - Signed informed consent - Women did notno opt-out for making their smear available for research - Women who undergo a colposcopy examination because of a positive HPV test and an abnormal PAP-smear. - Women in follow up after a radical vaginal trachelectomy - Women diagnosed with cervical cancer
Exclusion criteria
Exclusion criteria: - Women who are pregnant during the colposcopy or surgery - Women who are not able to understand the study-information - Women whom did not signed informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference in gene-expression profiles between cervical smears from healthy women and women with CIN1, CIN2, CIN3 and cancer lesions | — |
Secondary
| Measure | Time frame |
|---|---|
| The second objective is to evaluate how gene expression profiles in smears relate to gene expression profiles in matching dysplastic or cancer tissue. | — |
Countries
Netherlands
Contacts
Public ContactP.L.M Zusterzeel
Radboud Universitair Medisch Centrum
Outcome results
None listed