EXercise magnetic resonance imaging in Patients with Obesity aSsociated heart failURe with preserved Ejection fraction (EXPOSURE) study

EXercise magnetic resonance imaging in Patients with Obesity aSsociated heart failURe with preserved Ejection fraction (EXPOSURE) study - EXPOSURE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51285

Enrollment

Registered

2022-10-26

Start date

2024-01-16

Completion date

Unknown

Last updated

2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adipose tissue around the heart Heart failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Signs and symptoms of HF according to the Europeans Society of Cardiology guideline. 2. LV ejection fraction >=40%. 3. HFA-PEFF score >=5 or HFA-PEFF score 2-4 in combination with positive stress test 4. >18 years of age 5. Able to perform a bicycle exercise test 6. Willing to sign informed consent

Exclusion criteria

Exclusion criteria: 1. Body weight >140 kg 2. Uncontrolled atrial fibrillation or other significant arrhythmia with resting heart rate >110 bpm during the assessment 3. Contraindications for CMR (e.g. claustrophobia, implanted cardiac devices) 4. Myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft

Design outcomes

Primary

Measure	Time frame
Patients will be stratified according to high (>=100 ml/m2) and low (	—

Secondary

Measure	Time frame
Pre-specified secondary outcome parameters between the subgroups are: 1) VO2-max, 2) LV and right ventricular (RV) diastolic strain rate, 3) slope of early LV/RV filling, 3) left and right atrial reservoir strain and emptying fraction, 4) pulmonary artery distensibility and pulsatility and 5) cardiac output, all at peak exercise. The amount of epicardial fat will be correlated with change in LV eccentricity index from rest to peak exercise, change in LV/RV diastolic strain rate, change in slope of LV/RV filling, change in atrial reservoir strain and emptying fraction, change in pulmonary artery distensibility and pulsatility, and change in cardiac output. All results will be also compared between men and women.	—

Measure

Time frame

Pre-specified secondary outcome parameters between the subgroups are: 1) VO2-max, 2) LV and right ventricular (RV) diastolic strain rate, 3) slope of early LV/RV filling, 3) left and right atrial reservoir strain and emptying fraction, 4) pulmonary artery distensibility and pulsatility and 5) cardiac output, all at peak exercise. The amount of epicardial fat will be correlated with change in LV eccentricity index from rest to peak exercise, change in LV/RV diastolic strain rate, change in slope of LV/RV filling, change in atrial reservoir strain and emptying fraction, change in pulmonary artery distensibility and pulsatility, and change in cardiac output. All results will be also compared between men and women.

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Countries

Netherlands

Outcome results