Analysis of the immunological and virological profile of unvaccinated and vaccinated measles cases to develop a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.

Analysis of the immunological and virological profile of unvaccinated and vaccinated measles cases to develop a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection. - Diagnostic Algorithm to Classify Contagiousness of Measles cases (DIAGCCOM)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51273

Enrollment

Registered

2021-12-16

Start date

2023-11-15

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

measles morbillivirus

Interventions

None listed

Eligibility

Age

2 Years to 64 Years

Inclusion criteria

Inclusion criteria: • Older than 2 years of age (vaccination with the MMR vaccine is performed at 14 months of age) • Laboratory confirmed measles case (by PCR and/or IgM serology) or suspected measles case with an epidemiological link to a laboratory-confirmed measles case • Recorded MMR vaccination status • The (suspected) measles case (and parents/legal guardians) have to be willing and able to participate in the trial according to procedure • Presence of a signed informed consent (from the [suspected] measles case or the parents/legal guardians) • Additional inclusion criterium for the additional blood sample: at least 9 years of age and born after 1965.

Exclusion criteria

Exclusion criteria: • Unknown MMR vaccination status • Below 2 years of age • Medical conditions that will severely affect immunological responses to vaccinations or measles virus infections, known or suspected immunodeficiency disease. • Use of immunosuppressive medication • For the additional blood sample: below 9 years of age or born before 1965.

Design outcomes

Primary

Measure	Time frame
The main study parameter is detection of measles viral RNA load in oropharyngeal swabs and saliva.	—

Secondary

Measure	Time frame
Secondary study parameters are: • Detection of measles infectious virus in pharyngeal swabs • Level of local and systemic measles-virus specific antibody responses, in relation to the primary virological endpoints. • Proportion of contact of measles case that resulted in measles virus transmission • Severity of disease • Determination of quantitative and qualitative measles-specific immunity in vaccinated and unvaccinated measles cases.	—

Measure

Time frame

Secondary study parameters are: • Detection of measles infectious virus in pharyngeal swabs • Level of local and systemic measles-virus specific antibody responses, in relation to the primary virological endpoints. • Proportion of contact of measles case that resulted in measles virus transmission • Severity of disease • Determination of quantitative and qualitative measles-specific immunity in vaccinated and unvaccinated measles cases.

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Countries

Netherlands

Outcome results