shaking tremor
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patients of any age over 18 who are capable of understanding and granting informed consent. 2. Patients who have undergone unilateral or bilateral DBS surgery for medication-refractory upper extremity tremor at least 5 years prior to recruitment. The upper limit for the time since surgery will be 15 years. Long intervals are specifically welcome. 3. Preoperative diagnosis of ET, ET plus or isolated dystonic tremor as defined by the tremor task force of the international Parkinson and Movement Disorders Society consensus in 2018 (Bhatia et al., 2018). 4. Availability of retrospective clinical baseline and early postoperative data, including tremor scales (see below 4.3.4). 5. Stable tremor medications and stimulation settings for at least 2 months prior to the study visit. 6. Patients must be able to follow the assessment procedure.
Exclusion criteria
Exclusion criteria: 1. Concomitant diseases that may confound the neurological findings. 2. DBS hardware malfunction (e.g., battery or electrode failure). 3. Significant cognitive impairment that may make patient unable to follow assessment procedure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome variables: Loss of benefit and categorical loss of benefit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome variables: Rebound tremor and overshoot benefit. | — |
Countries
Netherlands
Outcome results
None listed