This study will evaluate the skeletal muscle anabolic response following the ingestion of a protein rich meal Muscle Growth Muscle protein synthesis
Conditions
Interventions
Participants will undergo 2 test days. On one test day participants will
consume a meal containing meat, the other day participants will consume a meal
without meat.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Aged 65-85 years - Body mass index 18.5 * 30 kg/m2 - Healthy - Having given informed consent
Exclusion criteria
Exclusion criteria: - Allergy for one of the food items used - >5% weight change in the previous 6 months - Blood pressure >140/90 mmHg - Participating in a structured (progressive) exercise program - Smoking - Diagnosed musculoskeletal disorders - Diagnosed metabolic disorders (e.g. diabetes) - Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories). - Chronic use of gastric acid suppressing medication - Chronic use of anti-coagulants - Recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint will be mixed muscle protein synthesis rates over the full 6h post-prandial period following meal ingestion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma glucose, insulin and amino acid concentrations, as well as breath 13C/12C ratio following meal ingestion. | — |
Countries
Netherlands
Outcome results
None listed