COVID-19 vaccination
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Night shift workers in healthcare (18-50 years old) working predominantly night shifts (defined as at least 6 hours between 10PM and 7 AM) or work rotating shifts (morning, evening and night shifts). The control group are healthcare workers (18-50 years old) who only work during the day, with regular sleeptimes, an average sleep duration of at least 7 hours, and no history of night shift work in the last 6 months.
Exclusion criteria
Exclusion criteria: - Younger than 18 years or older than 50 years old. - Pregnant or have a wish to become pregnant within 6 months. - Regular medication regimen known to affect sleep [ or alertness - All regular contra-indications of the vaccines will be applied -Indication of prior exposure to COVID-19. -participants diagnosed with an immunedeficiency syndrome, any auto-immune or auto-inflammatory disease except atopic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • The immune response against SARS CoV-2 vaccination at several timepoints • Sleep duration and sleep quality measured objectively and subjectively around each vaccination.timepoint | — |
Secondary
| Measure | Time frame |
|---|---|
| • Circadian clock markers at baseline • Profile of gut microbiota by fecal samples • SARS-CoV-2 specific T cell responses • Immune response over time • Adverse reactions after SARS-CoV-2 vaccinations | — |
Countries
Netherlands
Outcome results
None listed