Thermoregulatoire aandoeningen (hitteberoerte en maligne hyperthermie) excessive hyperthermia Heat stroke
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Between 18 and 60 years of age - Willingness to provide written consent after proper information about the study objectives and procedures - Physically active lifestyle (endurance exercise, *2 times a week) Furthermore, we will apply specific inclusion criteria for the EHS and MHS group. - EHS group: a history of an EHS in the past 10 years that has resulted in physical complaints for at least 6 months. - MH group: a history of RYR1-related MH or MH susceptibility (MHS) according to the guidelines of the European Malignant Hyperthermia Group (EMHG), which states that an individual is MHS when an individual have a diagnostically confirmed RYR1 variant or a positive in vitro contracture test. Only one member per family will be included in order to ensure that we include a representative sample of the MHS population. - Control group: healthy age and sex matched peers.
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study: - Exclusion criteria associated with the use of the telemetric temperature capsule: I) a bodyweight
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the increase in core temperature (CBT) during exercise at a fixed metabolic heat production. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes relate to the thermoregulatory (i.e. skin temperature, heat production, sweat rate, heat balance) and cardiovascular responses (i.e. heart rate, blood pressure) to exercise in hot environmental conditions. | — |
Countries
Netherlands
Outcome results
None listed