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Neural and structural adaptation of human skeletal muscle to overstretch and overload through mechanical stimuli delivered by dynamometry and exoskeletons

Neural and structural adaptation of human skeletal muscle to overstretch and overload through mechanical stimuli delivered by dynamometry and exoskeletons - Neural and structural muscle adaptation to exercise

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON51207
Enrollment
30
Registered
2022-05-18
Start date
2022-01-01
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal cord injury stroke

Interventions

For the experiment, the exercise intervention will consist of maximal voluntary ankle eccentric plantarflexion contractions. Two training session will be performed per week for a training period of

Sponsors

University of Twente
Lead Sponsor

Eligibility

Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Age between 18 and 55, - legal capacity to give their consent at their own will

Exclusion criteria

Exclusion criteria: - neuromuscular disease, - carrier of infectious diseases (COVID19), - degenerative mental impairment, e.g. dementia, - inability to cooperate, e.g. due to cognitive deficits (in understanding instructions) or a level of motor impairment that does not permit execution of the intended tasks, - subjects suffering from known cardiac conditions (e.g., pacemakers, arrhythmias, and cardiac conduction disturbances) or peripheral neuropathy. - skin sensitivity or allergies as these are typical contraindications for the application of surface EMG electrodes via adhesive elements and conductive gels. - If participants have one of the following objects in their bodies: metal (splinters) (e.g., by working in the metal industry); pacemaker, pacemaker leads or an implanted defibrillator; an artificial heart valve/aorta valve or a stent; clips on blood vessels; implanted magnets in the jaw; fixed hearing aid, bladder stimulator, insulin pump, neurostimulator, baclofen pump, tissue expander; eye or ear implants; foreign materials implanted in the body; braces or metallic wire fixed behind teeth; piercings. Participants with these objects in/on their bodies have to be excluded as they must not be inside of a magnetic resonance imaging device - Dependency on one or more researchers of this project

Design outcomes

Primary

MeasureTime frame
The primary outcome of this study will be to relate muscle volume, fascicle length, and pennation angle to motor unit discharge rate, inter-spike interval, and recruitment threshold.

Secondary

MeasureTime frame
The secondary outcome of this study will be to compare muscle fascicle length changes and shortening velocity, and motor neuron discharge rate, inter-spike interval, and recruitment threshold before and after the training intervention.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)