scientific investigation of healthy subjects healthy
Conditions
Interventions
None listed
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy adult subjects with no history of neurological disorder/disease and no counter-indications to 3 Tesla MRI, EEG or to atomoxetine, and no personal relationship with the researchers will be included in this study. All participants will be right-handed with normal vision or contact lenses.
Exclusion criteria
Exclusion criteria: Significant history of head trauma, premature birth, learning disabilities, neurological or psychiatric illness. Heart arrhythmia, glaucoma, congenital eye diseases, hyperopia, myopia, hypertension and use of antidepressants or psychotropic medication and possible pregnancy (in adult females). MRI contra-indications, including metal implants and claustrophobia. Smoking more than five cigarettes a day - to avoid nicotine withdrawal effects during the study. Alcohol consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Behavioural measures: choice history, outcome history, learning performance, choice reaction time, and choice variability • Computational measures: model fit, estimated model parameters and variables • Psychophysiological measures: task-related and task-unrelated changes in pupil size • Brain activity measures: effect of atomoxetine on task-related evoked BOLD or EEG signal | — |
Secondary
| Measure | Time frame |
|---|---|
| •Psychometric measures: state anxiety, trait anxiety, emotional arousal (to be included as regressors for behavioural, fMRI and EEG data) •Physiological measures: salivary cortisol and alpha amylase (to be included as regressors for behavioural, fMRI and EEG data) | — |
Countries
Netherlands
Outcome results
None listed