Veroudering aging seniority
Conditions
Interventions
None listed
Sponsors
Anesthesiologie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Aged between 18 years of age and 90 years of age - Acceptable proficiency of the Dutch language - Healthy volunteers without physical or mental illness Comorbidity group In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Aged between 18 years of age and 90 years of age - Acceptable proficiency of the Dutch language - One of the underlying illnesses: neurodegenerative disease, diabetes mellitus type II or obesity (BMI>30), no other relevant comorbidity
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Porphyria - Known intolerance to components of the ALA plaster - Presence of mitochondrial disease - Pregnancy/lactation - Patients with skin lesions on the measurement location which impede measurements - Incapability to provide inform consent, due to a mental condition interfering with the ability to understand the provided information
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MitoPO2 (mmHg). Ten mitoPO2 (mmHg) baseline measurements will be performed on both the sternum and upper arm of all subjects. The mean and standard deviation of those measurements will compute the baseline mitoPO2 for every participant. | — |
Secondary
| Measure | Time frame |
|---|---|
| MitoVO2 (mmHg/second). Applying pressure on the probe will cause a temporary halt of circulation to the mitochondria. As the oxygen consumption continues, this will result in a time-dependent decrease in mitoPO2 from which the mitoVO2 can be calculated in mmHg/second. Three mitoVO2 measurements will be performed on both the sternum and the upper arm and the mean will be calculated for both. | — |
Countries
Netherlands
Outcome results
None listed