INSIDE-LRP: Non-Invasive Identification with Computed Tomography Coronary Angiography of Vulnerable Lipid-Rich Plaques

INSIDE-LRP: Non-Invasive Identification with Computed Tomography Coronary Angiography of Vulnerable Lipid-Rich Plaques - INSIDE-LRP

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51163

Enrollment

Registered

2021-02-02

Start date

2021-07-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Subject underwent computed tomography coronary angiography within the previous two months; 2. Subject is scheduled for subsequent invasive coronary angiography.

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: 1. Acute coronary syndrome with ST-segment elevation; 2. Acute coronary syndrome without ST-segment elevation with hemodynamic instability or ongoing ischemia, requiring urgent revascularization; 3. Estimated glomerular filtration rate

Design outcomes

Primary

Measure	Time frame
The ability of CTCA to detect a LRP (LCBImm4 > 400) as identified by NIRS	—

Secondary

Measure	Time frame
o The CTCA plaque characteristics of lipid-rich plaques (i.e. plaques with LCBImm4 >400), as identified with NIRS. o The CTCA characteristics of near-lipid-rich coronary plaques with LCBImm4 of *250 and 400) and near-lipid-rich plaques (LCBImm4 between 250 and 400).	—

Countries

Netherlands

Outcome results