Confocal lAser EndomicroScopy in patients with non-resolving Acute Respiratory failure

Confocal lAser EndomicroScopy in patients with non-resolving Acute Respiratory failure - CAESAR

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51162

Enrollment

Registered

2021-02-02

Start date

2021-03-03

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute respiratory distress syndrome non resolving acute respiratory insufficiency in mechanically ventilated patients

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - *18 years of age - Non-resolving acute respiratory failure mandating a standard diagnostic bronchoscopy with broncho-alveolar lavage

Exclusion criteria

Exclusion criteria: - Inability and willingness to provide informed consent by family-members -ECMO - Inability to comply with the study protocol

Design outcomes

Primary

Measure	Time frame
identification of specific CLE patterns of the alveolar compartment of COVID 19 invasivally ventilated patients	—

Secondary

Measure	Time frame
-Description of how CLE patterns change over time within the same patients - Descriptive correlation of CLE patterns with Chest CT - Descriptive correlation of CLE patterns with lung ultrasound - Descriptive correlation of CLE patterns with cytology from bronchoalveolar lavage -Descriptive correlation of in vivo CLE patterns with histology (when available) -Descriptive correlation of ex vivo CLE images with histology (when available) -Time of procedure - Proportion of successful imaging of alveolar compartment	—

Measure

Time frame

-Description of how CLE patterns change over time within the same patients - Descriptive correlation of CLE patterns with Chest CT - Descriptive correlation of CLE patterns with lung ultrasound - Descriptive correlation of CLE patterns with cytology from bronchoalveolar lavage -Descriptive correlation of in vivo CLE patterns with histology (when available) -Descriptive correlation of ex vivo CLE images with histology (when available) -Time of procedure - Proportion of successful imaging of alveolar compartment

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Countries

Netherlands

Outcome results