Defining type 2 asthma phenotypes based on clinical, biological and functional parameters using cluster analysis.

Defining type 2 asthma phenotypes based on clinical, biological and functional parameters using cluster analysis. - The 2CLASS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51135

Enrollment

120

Registered

2021-05-31

Start date

2021-10-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma with eosinophilic inflammation Type 2 asthma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >=18 year (Adult) Confirmed asthma diagnosis by a health professional Under treatment in secondary care for asthma Using ICS on daily basis At least one type 2 asthma characteristic present: - High blood eosinophils - High sputum eosinophils - High fractional exhaled nitric oxide (FeNO) - Allergen mediated asthma (allergic symptoms supported by at least one positive specific blood IgE test)

Exclusion criteria

Exclusion criteria: Use of biologicals or prednisolone Asthma exacerbation within 6 weeks before inclusion Not able to perform lung function test or having a contraindication to do so Current smoker or more than 10 pack-years Has been tested positively for COVID-19 within last two months Other respiratory diseases than asthma

Design outcomes

Primary

Measure	Time frame
The main endpoint of this study is the formation of type 2 asthma clusters based on patient and asthma characteristics.	—

Secondary

Measure	Time frame
Secondary, the found clusters will be compared and clinically interpreted.	—

Countries

Netherlands

Outcome results