paradoxal vocal fold motion disorder vocal cord dysfunction
Conditions
Interventions
-Cold, dry air by using a climate chamber (5-10 dgrC)
Sponsors
Medisch Spectrum Twente
Eligibility
Age
12 Years to 64 Years
Inclusion criteria
Inclusion criteria: -Age 10 to 24 years -Clinical suspicion of EILO and planned for ECT -Ability to perform exercise challenge test on treadmill or bike -Written informed consent of patient and/or parents or legal guardians
Exclusion criteria
Exclusion criteria: -Other severe cardiopulmonary disease -Baseline FEV1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: The main study parameter is the difference of occurrence of EILO (defined as Maat sumscore >2) during CLE testing at room temperature and in cold, dry air. | — |
Secondary
| Measure | Time frame |
|---|---|
| -EILO grade score (Maat score; glottic or supraglottic, grade 1-3) -Symptoms reported -Duration until start of symptoms after start of exercise, and duration until peak dyspnoea -VAS score: before exercise, at peak level of dyspnoea and 2 minutes after exercise -Physiologic measurements: breathing frequency, heart rate, heart rate recovery time, blood pressure -EMG measurements of diaphragm before and after exercise -Respiratory induction plethysmography (RIP) during exercise -Lung function with in- and expiratory flow volume loops before and at 1, 3, 6 minutes after exercise -FOT measurements before and after exercise -Audio-visual recordings: breath sounds, observed breathing pattern -Max Wattage/kg or maximum running pace -Questionnaire about perceived symptoms and influence of environmental factors -Astma control test | — |
Countries
Netherlands
Outcome results
None listed