pijnbehandeling neuropathic pain pain PK/PD
Conditions
Interventions
Administration of S-ketamine mucosal patch (50 mg and 100 mg)
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - aged 18-45 years, - body mass index > 19 and
Exclusion criteria
Exclusion criteria: - Presence or history of any medical or psychiatric disease (incl. a history of substance abuse, anxiety, or the presence of a painful syndrome); - Use of any medication in the three months prior to the study (incl. paracetamol or other pain killers); - Use of more than 21 alcohol units per week; - Use of illegal substances, including cannabis, in the 4 weeks prior to the study; - A positive urinary drug test or a breath alcohol test at screening or on the morning of the experiment; - Pregnancy, lactating or a positive pregnancy test on the morning of the experiment; - Participation in another drug trial in the 60 days prior to dosing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Plasma concentrations eskatemine and esnorketamine; -Antinociceptive responses to pressure pain, electrical pain and heat pain. | — |
Secondary
| Measure | Time frame |
|---|---|
| Response to Bowdle and Bond & Lader questionnaires. | — |
Countries
Netherlands
Outcome results
None listed