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Another's pain vs my gain: The causal role of the prefrontal cortex in prosocial decision-making

Another's pain vs my gain: The causal role of the prefrontal cortex in prosocial decision-making - PainGain

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON51114
Enrollment
60
Registered
2020-12-21
Start date
2021-10-26
Completion date
Unknown
Last updated
2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The experiment is conducted on healthy participants. In the proposed project we test behaviour during social cognition (e.g. affective sharing) and prosocial behaviour empathie feelings

Interventions

None listed

Sponsors

Universiteit van Amsterdam
Lead Sponsor

Eligibility

Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: healthy participants, age 18-35, proficiency with english, right-handedness

Exclusion criteria

Exclusion criteria: Participants without a high proficiency level in the English language will be excluded from the study. For the TMS part they will be asked to fill a standard questionnaire for neuromodulation studies to exclude any participant with contraindications to brain stimulation. EXAMPLE OF SAFETY SCREENING * Have you ever: o Had an adverse reaction to TMS? o Had a seizure? o Had an EEG? o Had a stroke? o Had a head injury (include neurosurgery)? * Do you have any metal in your head (outside of the mouth,) such as shrapnel, surgical clips, or fragments from welding or metalwork? (Metal can be moved or heated by TMS) * Do you have any implanted devices such as cardiac pacemakers, medical pumps, or intracardiac lines, cochlear implants, implanted brain stimulators, implanted defibrillator? (TMS may interfere with electronics and those with heart conditions are at greater risk in event of seizure) * Do you suffer from frequent or severe headaches? * Have you ever had any other brain-related condition? * Have you ever had any illness that caused brain injury? * Are you taking any medications? (e.g. Tricyclic anti-depressants, neuroleptic agents, and other drugs that lower the seizure threshold) * If you are a woman of childbearing age, are you sexually active, and if so, are you not using a reliable method of birth control? * Does anyone in your family have epilepsy? * Do you need further explanation of TMS and its associated risks? Participants will complete the Stress Tolerance Short Questionnaire as an additional screening. If participants score over 50 in this questionnaire, we will advise them not to continue with the study.

Design outcomes

Primary

MeasureTime frame
The primary outcome of the study will be the participant's performance in our behavioral task (choice behavior).

Secondary

MeasureTime frame
We will also use other behavioral indicators such as the proportion of prosocial choices and reaction time as secondary indicators.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)