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The impact of clot composition on its mechanical properties

The impact of clot composition on its mechanical properties - Clot composition and mechanical properties

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON51109
Enrollment
25
Registered
2022-01-13
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

None listed

Sponsors

Erasmus MC, Universitair Medisch Centrum Rotterdam
Lead Sponsor

Eligibility

Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Subjects should sign up voluntarily - Subjects should be healthy - Subjects should be between 18 and 70 years old - Subjects should give written informed consent

Exclusion criteria

Exclusion criteria: - Subjects with diseases known to affect coagulation (e.g. cancer, diabetes, cardiovascular disease) - Subjects using medication interfering with coagulation

Design outcomes

Primary

MeasureTime frame
Blood from healthy volunteers will be used as a source for red blood cells, platelets, immune cells, fibrinogen, plasma. Using these components, we will optimize to generate clot analogues of various composition for mechanical testing and imaging. The main study endpoints will be to establish and quantify the relationship between clot composition -for both homogeneous and heterogeneous clost- and the -global and local- mechanical properties and imaging features.

Secondary

MeasureTime frame
Not applicable.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)