Liquid biopsies for improving the pre-operative diagnosis of ovarian cancer

Liquid biopsies for improving the pre-operative diagnosis of ovarian cancer - OVI-DETECT

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51106

Enrollment

450

Registered

2021-01-21

Start date

2021-07-02

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer of the ovary ovarian cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Age >=18 years 2. Presence of a ovarian tumor and referred to specialized center for surgery based on: a. Any ultrasound model b. Subjective assessment of the referring gynecologist c. Normal Glomerular Filtration Rate (GFR): >60ml/min/1,73m2 3.General criteria: a. Understanding of Dutch language b. Fit for surgery (WHO 1-2) c. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Suspicion of advanced-stage of disease, e.g. ascites or peritoneal depositions 2. History of cancer (excl. BCC) within 5 years prior to inclusion 3. Multiple malignancies at the same time

Design outcomes

Primary

Measure	Time frame
The sensitivity and specificity of a new diagnostic algorithm including liquid biopsies, to differentiate patients with ovarian cancer from patients with a benign ovarian tumor.	—

Secondary

Measure	Time frame
1. Calculation of cost-effectiveness of addition of plasma liquid biopsy measurement in the triage of patients with an ovarian tumor. 2. Psychological burden of the uncertainty of having cancer or not before surgical treatment.	—

Countries

Netherlands

Outcome results