Anxiety disorder, acquired brain injury Anxiety disorder, acquired brain injury
Conditions
Interventions
None listed
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Potential participants are selected from an ambulant patient population and a inpatient population that are following standard outpatient clinical care that is composed of multidisciplinary treatment for anxiety and/or depression symptoms using CBT (standard, or adapted to cognitive problems) in which cognitive, behavioural and exposure techniques are used. A multidisciplinary team in which a neurologist and/or a psychiatrist participates indicate whether participants are regarded to be cognitive, intellectually and physically fit enough to profit from CBT. Patients in this treatment program are therefore regarded to be fully able to provide informed consent and be eligible to participate in the current study. Patients that receive care at this clinic typically have light to moderate brain damage in a chronic phase and are medically and neurologically stable, have mild to moderate cognitive dysfunction, are independent in terms of activities of daily living or receive some sort of coaching, but with persistent psychological symptoms that are difficult to alleviate. No further criteria are set for the severity of the symptoms. In order to be eligible to participate in this study, a subject must meet all of the following criteria: age 18-65 years, with acquired brain injury (chronic phase) and anxiety and/or depression symptoms, that are selected for CBT by a multidisciplinary team as part of standard care typically for Thalamus specialized mental care outpatient clinic (Pro Persona Wolfheze).
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: severe comorbidity (diagnosed with severe chronic depression, bipolar disorder and/or psychosis) or substance abuse disorder, hearing problems and inability to read or speak Dutch. Medication, age, gender and diagnosis are used as cofounders for the analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are 1) the proportion of patients with ABI who are classified into the dysfunctional poor extinction class, that is hypothesized to be at least similar or potentially larger to the proportion in an anxiety disordered population, and significantly different from a healthy population, both derived from previous studies. 2) the association between the extinction class membership and executive strength, or, a composite score of cognitive switching, updating and inhibition. Furthermore, analysis will be performed to investigate the potential association between cognitive flexibility and extinction class membership. | — |
Countries
Netherlands
Contacts
Public ContactH.A. Anema
Universiteit Utrecht
Outcome results
None listed